Dana Evans scored 13 points and No. 4 Louisville used a 16-0 run spanning halftime to take command and beat Virginia 71-49 on Thursday night.
Asia Durr added 12 points and Sam Fuehring 11 for the Cardinals (24-2, 11-2 Atlantic Coast Conference), who bounced back from a loss to No. 14 Miami on Sunday.
Jocelyn Willoughby had 16 points and 13 rebounds to lead Virginia (10-16, 4-9) and Lisa Jablonowski had 13. The Cavaliers led 28-25 at halftime, but the Cardinals scored the first 12 points after halftime to open a 37-28 lead. They wound up outscoring the Cavaliers 46-21 in the second half.
Virginia was seeking its first victory against a ranked team since it beat No. 4 Florida State 60-51 on Feb. 16, 2017.
Louisville: The Cardinals arrived averaging 79.2 points and having topped 100 three times but struggled in the first half. Leading scorer Asia Durr missed six of her seven shots and the team was 11 for 32 (34.4 percent) in the half, including just 3 for 16 from 3-point range. After halftime, they made 16 of 28 shots (66.7 percent) and 7 of 11 from beyond the 3-point arc.
Virginia: Junior Jocelyn Willoughby became the third Virginia player in the past two seasons to go over 1,000 career points when she made a jumper with 1:55 left in the third period, joining Lauren Moses and Aliyah Huland El, who reached the milestone 15 days apart last season. Willoughby is the 35th 1,000-point scorer in program history, and junior Dominique Toussaint scored just two points against the Cardinals and is 32 points away for also reaching 1,000.
Louisville: The Cardinals are at home against Boston College on Sunday.
Virginia: The Cavaliers are at home against Georgia Tech on Sunday.